Identification of lncRNAs during B cell lineage commitment

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670472
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Hematology
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Tomokatsu Ikawa 国立研究開発法人理化学研究所, 統合生命医科学研究センター, 上級研究員 (60450392)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: B細胞分化 / 長鎖ノンコーディングRNA / 造血幹細胞 / 運命決定 / エピジェネティクス

Outline of Final Research Achievements

B lymphocytes are generated from pluripotent hematopoietic stem cells (HSCs) through a successive series of lineage restriction processes. Although many transcription factors and epigenetic modifiers were found to regulate the B cell lineage commitment, the exact mechanisms were yet to be determined. We have recently established an ideal system that can be used to examine gene regulatory networks during lymphoid lineage specification from HSCs. In this study, we looked for novel long non coding (lnc) RNAs that could regulate B cell fate determination using this system. We have succeeded in identifying the lncRNAs that may be involved in the specification and commitment of HSCs toward the B cell lineage.

Free Research Field

免疫学