2015 Fiscal Year Final Research Report
Development of complement component MASP-1/3 inhibitors for treatment of lupus animal models.
| Project/Area Number |
26670478
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MACHIDA TAKESHI 福島県立医科大学, 医学部, 助教 (80583632)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAHASHI MINORU 福島県立医科大学, 医学部, 准教授 (00285024)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 補体 / レクチン経路 / 第二経路 / MASP-1/3 / MAp44 |
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| Outline of Final Research Achievements |
We generated two recombinant proteins（MAp44-Ig, MAp44-fH）to threat diseases that are associated with activation of the complement lectin and alternative pathways such as lupus. In vitro experiments using mannan-coated microplates showed that MAp44-fH has stronger effect on the lectin and alternative pathway inhibition compared to MAp44-Ig. In vivo experiments by using sera from mice that received peritoneal administration of MAp44-fH showed inhibitory effect of the lectin and alternative pathways. MAp44-fH will be administrated to murine lupus models afterwards.
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| Free Research Field |
補体学
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