2016 Fiscal Year Final Research Report
Study of Kawasaki Disease
| Project/Area Number |
26670489
|
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
|
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
|
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 血管炎 / コレクチン |
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| Outline of Final Research Achievements |
Kawasaki disease generally develops due to microbe infection and is a disease characterized by intense inflammation of the blood vessel in the whole body. Applicants focused on CL-P1 and went the inspection of the hypothesis to bring about sustained blood vessel inflammation in this study. Firstly, they chose CL-P1 as a candidate to bind CRP and evaluated the activation of the complement to on this occasion that an ascent of sudden CRP was generated when some infection and inflammation happened. They showed that CRP trapped by CL-P1 draws C1q, and activates a classical pathway at this place. Furthermore, it was revealed that this reaction activates the alternative pathway. These results suggest the possibility of exercised new complement activation mechanism through CRP.
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| Free Research Field |
生化学
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