2015 Fiscal Year Final Research Report
Development of dual-modality SPECT/fluorescent probe
| Project/Area Number |
26670550
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Chiba University |
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Principal Investigator |
Uehara Tomoya 千葉大学, 薬学研究科(研究院), 准教授 (10323403)
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| Co-Investigator(Renkei-kenkyūsha) |
SUZUKI Noriyuki 千葉大学, 大学院薬学研究院, 准教授 (10376379)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | SPECT / 蛍光 / センチネルリンパ節 |
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| Outline of Final Research Achievements |
To develop the dual-modality probes that contain both a radiotracer and a fluorescent label, we synthesized several Re-complex using Re(CO)3 core to prepare fluorescent Re-complex. Among them, when the donor groups of the ligand are dipyridyl (Dp) and benzoisonitrile (CN-Bz), the rhenium complexe (Re(CO)3DpCN-Bz) was fluorescent.Re(CO)3DpCN-Bz will be conjugated to biomolecules to prepare sentinel node detecting agent.
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| Free Research Field |
放射性薬品化学
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