Development of MR molecular imaging for brain amyloid detection: PET/MRI approach

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670564
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Kagoshima University
• Principal Investigator: YOSHIURA Takashi 鹿児島大学, 医歯学域医学系, 教授 (40322747)
• Co-Investigator(Kenkyū-buntansha): HIWATASHI Akio 九州大学, 大学病院, 助教 (30444855) ; TOGAO Osamu 九州大学, 大学病院, 助教 (10452749) ; YAMASHITA Koji 九州大学, 大学病院, 助教 (80546565) ; BABA Shingo 九州大学, 大学病院, 講師 (80380450) ; ISODA Takuro 札幌医科大学, 医学部, 助教 (90452747) ; OHYAGI Yasumasa 愛媛大学, 医学系研究科, 教授 (30301336) ; KUMAZAWA Seiji 北海道科学大学, 保健医療学部, 教授 (50363354) ; HONDA Hiroshi 九州大学, 医学研究院, 教授 (90145433)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: アルツハイマー病 / アミロイド / MRI / PET

Outline of Final Research Achievements

We performed an in-vitro phantom experiment and revealed that beta-amyloid can be detected by means of chemical exchange saturation transfer (CEST) imaging. We evaluated the effect of skull in PET/MRI measurement of PIB accumulation. As a results, we found that presence of skull led to significant underestimate of SUV in the cortex and the cerebellum, in comparison with those by PET/CT. This finding suggested a need for customized standard of SUV and SUVr for PET/MRI detection of amyloid. We developed a more objective and reproducible method for amyloid detection in PIB-PET/MRI takin advantage of MRI morphological information.

Free Research Field

放射線医学