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2015 Fiscal Year Final Research Report

Development of MR molecular imaging for brain amyloid detection: PET/MRI approach

Research Project

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Project/Area Number 26670564
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionKagoshima University

Principal Investigator

YOSHIURA Takashi  鹿児島大学, 医歯学域医学系, 教授 (40322747)

Co-Investigator(Kenkyū-buntansha) HIWATASHI Akio  九州大学, 大学病院, 助教 (30444855)
TOGAO Osamu  九州大学, 大学病院, 助教 (10452749)
YAMASHITA Koji  九州大学, 大学病院, 助教 (80546565)
BABA Shingo  九州大学, 大学病院, 講師 (80380450)
ISODA Takuro  札幌医科大学, 医学部, 助教 (90452747)
OHYAGI Yasumasa  愛媛大学, 医学系研究科, 教授 (30301336)
KUMAZAWA Seiji  北海道科学大学, 保健医療学部, 教授 (50363354)
HONDA Hiroshi  九州大学, 医学研究院, 教授 (90145433)
Project Period (FY) 2014-04-01 – 2016-03-31
Keywordsアルツハイマー病 / アミロイド / MRI / PET
Outline of Final Research Achievements

We performed an in-vitro phantom experiment and revealed that beta-amyloid can be detected by means of chemical exchange saturation transfer (CEST) imaging. We evaluated the effect of skull in PET/MRI measurement of PIB accumulation. As a results, we found that presence of skull led to significant underestimate of SUV in the cortex and the cerebellum, in comparison with those by PET/CT. This finding suggested a need for customized standard of SUV and SUVr for PET/MRI detection of amyloid. We developed a more objective and reproducible method for amyloid detection in PIB-PET/MRI takin advantage of MRI morphological information.

Free Research Field

放射線医学

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Published: 2017-05-10  

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