Development of novel biomarkers for pancreas cancer using a high accuracy blood cell gene expression analysis.

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670570
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Dokkyo Medical University (2015); National Institute of Radiological Sciences (2014)
• Principal Investigator: Kobashi Gen 獨協医科大学, 医学部, 教授 (60270782)
• Co-Investigator(Kenkyū-buntansha): SAITO Toshiyuki 放射線医学総合研究所, 重粒子医科学センター, 研究員 (90205667)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 膵がん / バイオマーカー / 遺伝子発現 / トランスクリプトーム

Outline of Final Research Achievements

To develop novel biomarkers useful for detecting and monitoring pancreas cancer, 17 cases and 4 control were obtained. A high accuracy large-scale gene expression analysis of 8919 mRNAs revealed difference of transcriptome between the cases and controls. It is suggested that studies focusing on differentially-expressed transcripts might discriminate cases from controls with high accuracy in the future.

Free Research Field

予防医学