2016 Fiscal Year Final Research Report
RNA edition as an escape mechanism of malignant pleural mesothelioma cells from cell stress
| Project/Area Number |
26670624
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory surgery
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| Research Institution | Hokkaido University |
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Principal Investigator |
Kaga Kichizo 北海道大学, 大学病院, 講師 (80224335)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 悪性胸膜中皮腫 |
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| Outline of Final Research Achievements |
Over expression of COPA, neither edited nor non-edited RNA of inhibited growth of malignant pleural mesothelioma. Over expression did not affect migration and invasion of malignant pleural mesothelioma.
High density culture increased COPA expression. Culture under either hypoxia + low glucose, or hypoxia +high glucose revealed that glucose concentration does not influence COPA expression.
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| Free Research Field |
呼吸器外科
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