2016 Fiscal Year Final Research Report
New therapeutic strategy for non-small cell lung cancer by REIC gene therapy
Project/Area Number |
26670627
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Respiratory surgery
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Research Institution | Okayama University |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Keywords | REIC遺伝子 / 非小細胞肺癌 / 遺伝子治療 |
Outline of Final Research Achievements |
REIC is down-regulated in many human cancer cells and is considered to function as a tumor suppressor. REIC-expressing adenovirus vector (Ad-REIC) induces endoplasmic reticulum (ER) stress and cancer-specific apoptosis in human cancers. We examined the therapeutic impact of Ad-REIC on non-small cell lung cancer and malignant pleural mesothelioma. We examined the direct anti-tumor effect of Ad-REIC gene therapy on non-small cell lung cancer and malignant pleural mesothelioma cell lines in vitro, and the distant bystander effect using immunocompetent mouse allograft models with bilateral flank tumors. Ad-REIC treatment showed antitumor effect in many lung cancer and malignant pleural mesothelioma cell lines in vitro. In an in vivo model, Ad-REIC treatment inhibited the growth not only of directly treated tumors but also distant untreated tumors. Ad-REIC treatment not only had a direct antitumor effect but also an indirect bystander effect through stimulation of the immune system.
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Free Research Field |
呼吸器外科学・分子腫瘍学
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