2015 Fiscal Year Final Research Report
Development of ALA-PET guided sonodynamic therapy for malignant gliomas
| Project/Area Number |
26670632
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurosurgery
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TERASAKA SHUNSUKE 北海道大学, 医学研究科, 准教授 (10447055)
KUDO NOBUKI 北海道大学, 情報科学研究科, 准教授 (30271638)
SHIGA TORU 北海道大学, 医学研究科, 准教授 (80374495)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 神経膠腫 / 音響力学療法 / ポルフィリン誘導体 / アミノレブリン酸 / PET / 超音波 |
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| Outline of Final Research Achievements |
Malignant glioma is a poor prognosis cancer despite of multidisciplinary treatment such as aggressive surgery and chemoradiotherapy. Thus there has been a need for new therapeutic approaches to control deeply migrated tumor cells. For this aim, we investigated the efficacy of sonodynamic therapy (SDT) using sonosensitizers including 5-aminolevulinic acid, protoporphyrinⅨ, and talaporfin sodium on glioma cells. These substances have been known to be accumulated in glioma cell and are expected to have cytotoxic effect by sonication. Our in vitro study demonstrated that the cytotoxicity of sonication on glioma cells was enhanced by each sonosensitizers. And induction of apoptosis was suggested to be a major mechanism of cell death. While the efficacy of SDT may be depend on the degree of intracellular accumulation of sonosensitizer. Though further investigations will be necessary, our preliminary result showed a potential of STD with sonosensitizers for glioma treatment.
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| Free Research Field |
脳腫瘍
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