2016 Fiscal Year Final Research Report
The development of fluorescent-PET dual tracer for malignant gliomas
Project/Area Number |
26670642
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Neurosurgery
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Research Institution | Osaka University |
Principal Investigator |
Takano Koji 大阪大学, 医学系研究科, 招へい教員 (90649203)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Keywords | ALA / PET / 脳腫瘍 / 術中蛍光診断 / 術前画像診断 / chemical imaging / molecular imaging / ナビゲーション |
Outline of Final Research Achievements |
This research aimed at developing a new PET tracer, which clarifies the correlation between intraoperative fluorescence diagnosis using 5-ALA and preoperative image diagnosis using MRI or PET (FDG, 11C-Methionine, etc.). As the candidate, a newly developed PET tracer, MALA (derivative of 5-ALA) was analyzed in vitro and in vivo. As a result, it was confirmed that MALA accumulates in a malignant tumor cell line, and that MALA accumulation significantly correlates with the accumulation of PPIX, a tracer for intraoperative fluorescence diagnosis using 5-ALA. MALA could be the PET tracer consistent with the purpose.
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Free Research Field |
脳腫瘍
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