Identification of hemodynamic risk factors for the development of cerebral aneurysms using high-resolution computational blood flow analysis

2016 Fiscal Year Final Research Report

• Project/Area Number: 26670647
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Neurosurgery
• Research Institution: Tohoku University
• Principal Investigator: SHIMOGONYA Yuji 東北大学, 学際科学フロンティア研究所, 助教 (30552575)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 脳動脈瘤 / 血流 / 血行力学 / 計算流体力学 / wall shear stress

Outline of Final Research Achievements

The purpose of this study was to identify the hemodynamic risk factors associated with the development of cerebral aneurysms. We constructed the patient-specific arterial models of middle cerebral artery (MCA) aneurysm based on CT images, and then approximately reconstructed the MCA models just before aneurysm development by virtually removing the aneurysm. Blood flow analyses for their models were performed with the computational fluid dynamics technique to compare hemodynamic metrics such as wall shear stress (WSS) between the aneurysm development site and normal site. A hemodynamic metric that quantifies WSS disturbances with multidirectional fluctuations was significantly higher at the aneurysm development site than the normal site. The results suggest that the multidirectionally disturbed WSS plays an important role in the development of cerebral aneurysms.

Free Research Field

生体流体力学