Development of a bifunctional, anti-resorptive and pro-ostegenic, compound

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670656
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: The University of Tokyo
• Principal Investigator: Honma Masashi 東京大学, 医学部附属病院, 特任准教授 (60401072)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: シグナル伝達 / 骨代謝 / ナノ材料

Outline of Final Research Achievements

RANKL is widely recognized as a signal input molecule to stimulate osteoclastogenesis, however; we have found that the osteoblastic RANKL acts as an osteogenic signal acceptor for RANK incorporated into osteoclastic exosomes. In the present study, we aimed to develop a polymeric compound which mimics the properties of osteclastic exosomes which enable both the inhibition of RANKL forward signaling and the stimulation of RANKL reverse signaling. N-terminal biotinylation of W9 peptide, which has been shown to bind RANKL extracellular domain, resulted in the significant increase of pharmacological effect of W9 peptide.

Free Research Field

整形外科学