Derivation of human PSC-derived mesodermal cells

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670661
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Kyoto University
• Principal Investigator: Ikeya Makoto 京都大学, 学内共同利用施設等, 准教授 (20442923)
• Co-Investigator(Kenkyū-buntansha): TOGUCHIDA Junya 京都大学, 再生医科学研究所, 教授 (40273502)
• Co-Investigator(Renkei-kenkyūsha): SAKURAI Hidetoshi 京都大学, iPS細胞研究所, 准教授 (80528745) ; KIN Eiki 京都大学, 医学部付属病院, 助教 (90620344)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 中胚葉細胞

Outline of Final Research Achievements

Mesenchymal cells, including bone, cartilage, muscle, dermis, and blood cells, are mainly derived from mesoderm. Mesoderm is defined as a intermediate formed between ectoderm and endoderm in the developmental process, and is derived from primitive streak in the early stage and from tail bud in the late stage of development. Specific mesenchymal cells are derived from specific mesodermal cells, such as axial bone and cartilage from paraxial mesoderm, limb mesenchyme from lateral plate mesoderm, and notochord from axial mesoderm. In this grant, we performed induction, purification and evaluation of mesodermal cells differentiated form PSCs.

Free Research Field

発生生物学