2016 Fiscal Year Final Research Report
Investigation of the vasodilator involved in post reperfusion syndrome in liver transplantation
| Project/Area Number |
26670686
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 肝移植 / 再灌流症候群 / 弛緩性血管作動物質 |
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| Outline of Final Research Achievements |
Post reperfusion syndrome (PRS) is a serious complication during liver transplantation (LT) surgery that typically occurs after portal vein declamping and reflow of blood through liver graft vessels. PRS is mainly characterized by rapid decrease of blood pressure which is probably caused by some vasodilators released by reperfusion.
We tried to elucidate the vasodilating substance using plasma samples obtained from patients during post reperfusion period in LT. The result has suggested that adenosine triphosphate (ATP) is the candidate for the vasodilators.
PRS is closely related postoperative mortality and morbidity of LT patients. That is why the elucidation of the PRS mechanism could lead to LT patients' prognosis.
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| Free Research Field |
麻酔学
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