Pathological examination of tubal fimbria and blood circulating DNA measurement toward the ultra-early detection of fallopian tubal cancer

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670710
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: Tohoku University
• Principal Investigator: YAEGASHI Nobuo 東北大学, 大学病院, 教授 (00241597)
• Co-Investigator(Kenkyū-buntansha): TOYOSHIMA Masafumi 東北大学, 大学病院, 助教 (70451581)
• Co-Investigator(Renkei-kenkyūsha): KITATANI Kazuyuki 東北大学, 東北メディカル・メガバンク機構, 助教 (40539235)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 卵巣がん / 漿液性腺癌 / p53変異 / 卵管采 / DNA損傷 / トランスフェリン / 卵胞液

Outline of Final Research Achievements

Serous adenocarcinoma is the most common tissue type of ovarian cancer, and is thought to be originated from tubal fimbria in recent years. We are focusing on DNA damage response, which is considered the cause of p53 mutations, because serous ovarian cancer has p53 mutations even at the precursor lesions. Using γ-H2AX as a marker of DNA2 double strand breaks, we found that transferrin cause DNA damage response in cells. We confirmed that this is specifically dependent on transferrin receptor 1 by siRNA knockdown. The above results were published in the oncogene, and are considered to be a significant achievement in understanding the pathogenesis of ovarian cancer.

Free Research Field

産婦人科学、婦人科腫瘍学