2016 Fiscal Year Final Research Report
Radiation induced immunomodulatory effects in head and neck cancers
| Project/Area Number |
26670736
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Gunma University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 癌 / 放射線治療 / 免疫学 |
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| Outline of Final Research Achievements |
Radiotherapy is generally used as one of treatment modalities for head and neck cancer, and it has been known to not only kill cancer cells but also induce anti-tumor immune responses through the expression of immunostimulatory molecules and release various signaling molecules. In this study, immunomodulatory effect by radiotherapy (X-ray and heavy ion radiation) was investigated using head and neck squamous cell carcinoma cell lines. Heavy ion radiation more efficiently killed tumor cells compared to X-ray. Moreover, radiotherapy could enhance calreticulin expression and decrease CD47 expression on tumor cells. These results suggest that radiotherapy might promote successful induction of anti-tumor immune responses via acceleration of phagocytosis by decrease of CD47 molecule.
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| Free Research Field |
耳鼻咽喉科
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