Target specificity in the regeneration process of the injured recurrent laryngeal nerve.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26670744
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: Kumamoto University
• Principal Investigator: Yumoto Eiji 熊本大学, 大学院生命科学研究部(医), 名誉教授 (40116992)
• Co-Investigator(Renkei-kenkyūsha): SANUKI Tetsuji 熊本大学, 医学部附属病院 耳鼻咽喉科 頭頸部外科, 講師 (10335896) ; MASUDA Masako 熊本大学, 医学部附属病院 耳鼻咽喉科 頭頸部外科, 非常勤診療医師 (70346998) ; KUMAI Yoshihiko 熊本大学, 大学院生命科学研究部(医) 耳鼻咽喉科 頭頸部外科, 助教 (00555774)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 反回神経再生 / 標的特異性 / 過誤神経支配

Outline of Final Research Achievements

In order to analyze whether the destination of reinnervation of motor neuron was the natural target or not, implantation of Y-shape silicone tube was performed. Recurrent laryngeal nerve and ansa cervicalis nerve of rats were transected individually, and then each nerve stumps of recurrent laryngeal nerve and the central end of ansa cervicalis nerve stump were sutured to each end of Y-shape tube. After the certain periods, the connection of each nerve was analyzed. The results showed that Y-shape tube was too large for rats. Moreover, hyperplasia of fibrous scar tissue which is the reaction to the silicone implants disturbed the analysis. Choice of animal model and materials of Y-shape tube need be considered again.

Free Research Field

喉頭科学