Analysis of Pathogenesis and disease marker of ocular surface inflammatory diseases using lipid metabolomics

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670758
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: KINOSHITA SHIGERU 京都府立医科大学, 医学(系)研究科(研究院), 教授 (30116024)
• Co-Investigator(Kenkyū-buntansha): SAITOU Yoshirou 国立医薬品食品衛生研究所, 医薬安全科学部, 部長 (50215571) ; UETA Mayumi 京都府立医科大学, 医学研究科, 准教授 (60398386)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 眼表面炎症性疾患 / 脂質メディエーター / メタボロミクス

Outline of Final Research Achievements

We analyzed the lipid mediator of ocular surface inflammatory diseases using lipid metabolomics techniques and elucidate the plasma lipid profiling of atopic keratoconjunctivitis , eye complications type Stevens-Johnson syndrome, and healthy controls. We also compare between each ocular surface inflammatory disease and normal controls, and between various ocular surface inflammatory diseases, and found the difference in ocular surface inflammatory diseases. We also identified the molecules involved in the pathogenesis of ocular surface inflammatory diseases and the related specific marker of them.

Free Research Field

眼科学