2015 Fiscal Year Final Research Report
The receptor and inhibitor of Nucleophosmin
| Project/Area Number |
26670793
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Emergency medicine
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| Research Institution | Osaka Institute of Technology |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MARUYAMA Ikuro 鹿児島大学, 大学院医歯学総合研究科, 特任教授 (20082282)
MIURA Naoki 鹿児島大学, 農水産獣医学域獣医学系, 准教授 (80508036)
ITO Takashi 鹿児島大学, 大学院医歯学総合研究科, 講師 (20381171)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 外科系臨床医学 / 救急医学 / DAMPs / アラーミン / ヌクレオフォスミン / 受容体 |
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| Outline of Final Research Achievements |
Nucleophosmin, which is a nucleoprotein, is major multifunctional protein involved in ribosomal biogenesis, centrosome duplication, cell cycle progression, apoptosis, and cell differentiation. Recently, nucleophosmin is released from endotoxin-stimulated macrophages and induces inflammatory cytokines such as tumor necrosis factor-alpha and interleukin-6, suggesting that nucleophosmin might be an alarmin. However, nucleophosmin's receptor and inhibitor remain unclear. In this study, we found the a nucleophosmin's receptor.
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| Free Research Field |
医歯薬学
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