The presence and its significance of non-canonical action of decoy receptors

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670808
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Functional basic dentistry
• Research Institution: Okayama University
• Principal Investigator: TAKIGAWA MASAHARU 岡山大学, 医歯(薬)学総合研究科, 教授 (20112063)
• Co-Investigator(Kenkyū-buntansha): KUBOTA SATOSHI 岡山大学, 大学院医歯薬学総合研究科, 教授 (90221936) ; AOYAMA ERIKO 岡山大学, 大学院医歯薬学総合研究科, 助教 (10432650) ; NISHIDA TAKASHI 岡山大学, 大学院医歯薬学総合研究科, 准教授 (30322233) ; HATTORI TAKAKO 岡山大学, 大学院医歯薬学総合研究科, 助教 (00228488)
• Co-Investigator(Renkei-kenkyūsha): TAKAESU KAZUMI (河田 かずみ) 岡山大学, 大学院医歯薬学総合研究科, 助教 (10457228)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: decoy receptor / osteoprotegerin (OPG) / PDGFRL / CCN family / CCN2 / signaling / osteoclasts / chondrocytes

Outline of Final Research Achievements

In this study, we proposed a new concept showing the presence and its significance of non-canonical action of decoy receptor (-like) molecules by demonstrating 2 examples. 1) Osteoprotegerin (OPG) bound to CCN family protein 2 (CCN2), which binds to RANK and positively regulates RALK signaling, thereby inhibiting osteoclastogenesis via RANK signaling. 2) Platelet-derived growth factor receptor-like (PDGFRL) did not bind to PDGF which is the ligand for PDGF. Instead, PDGFRL did bind to CCN2 which plays important roles in chondrogenesis and endochondral ossification and another member of CCN family CCN3. These findings suggest that PDGFRL plays an important role in the cartilage biology, possibly by regulating the molecular behavior of CCN2. 3) We also found that c-type lectin receptor CD302 bound to CCN2, suggesting possible discovery of another example which supports our new concept.

Free Research Field

機能系基礎歯科学