Studies on molecular mechanisms in differentiation and dedifferentiation of adipocytes.

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670809
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Functional basic dentistry
• Research Institution: Hiroshima University
• Principal Investigator: Kanematsu Takashi 広島大学, 医歯薬保健学研究院, 教授 (10264053)
• Co-Investigator(Kenkyū-buntansha): ASANO SATOSHI 広島大学, 大学院医歯薬保健学研究院, 助教 (30570535) ; HARADA KAE 広島大学, 大学院医歯薬保健学研究院, 助教 (60432663) ; YAMAWAKI YOSUKE 広島大学, 大学院医歯薬保健学研究院, 助教 (90584061)
• Research Collaborator: OUE KANA 広島大学病院, 歯科診療医
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 脂肪細胞 / 分化 / 脱分化 / エネルギー代謝 / 脂肪代謝

Outline of Final Research Achievements

We produced PLC-related catalytically inactive protein-knockout (Prip-KO) mice. Prip-KO mice showed a lean phenotype. In this study, we examined whether PRIP is involved in adipocyte differentiation and/or dedifferentiation. Adipocyte differentiation was significantly inhibited in Prip-KO mice compared with wild-type mice. However, a feature of adipocyte dedifferentiation was similar between the two genotypes. This study demonstrated that PRIP regulates the process of adipocyte differentiation and hypertrophy. These findings are inspiring a novel therapeutic strategy for obese patients.

Free Research Field

薬理学、細胞生物学