2015 Fiscal Year Final Research Report
Elucidation of the pathogenesis of disuse osteoporosis and steroid-induced osteoporosis using Fkbp5 knockout mice
Project/Area Number |
26670811
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Functional basic dentistry
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Research Institution | Nagasaki University |
Principal Investigator |
KOMORI Toshihisa 長崎大学, 医歯薬学総合研究科(歯学系), 教授 (00252677)
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Co-Investigator(Renkei-kenkyūsha) |
MORIISHI Takeshi 長崎大学, 医歯薬学総合研究科(歯学系), 助教 (20380983)
FUKUYAMA Ryo 広島国際大学, 薬学部, 講師 (20389117)
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Keywords | グルココルチコイド / ステロイド性骨粗鬆症 / Fkbp5 / 骨細胞 / メカルカルストレス |
Outline of Final Research Achievements |
We are clarifying the functions of osteocyte network using osteoblast-specific Bcl2 transgenic mice, in which osteocyte network is completely disrupted. We identified Fk506 binding protein 5 (Fkbp5), which was induced in osteoblasts and osteocytes on unloaded condition in the presence of osteocyte network. Fkbp5 is a chaperon molecule, which binds to steroid receptor. To investigate the functions of Fkbp5 in bone, we generated Fkbp5 knockout (Fkbp5-/-) mice. Fkbp5-/- mice showed more severe reductions of bone mass at unloaded condition and in the treatment of glucocorticoid as compared with those in wild-type mice.
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Free Research Field |
骨代謝学
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