2015 Fiscal Year Final Research Report
The synthesis of new compounds that reveals anti-bacterial biofilm activity
| Project/Area Number |
26670816
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Pathobiological dentistry/Dental radiology
|
|---|
| Research Institution | Niigata University |
|---|
Principal Investigator |
Terao Yutaka 新潟大学, 医歯学系, 教授 (50397717)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ODA Masataka 新潟大学, 医歯学系, 准教授 (00412403)
DOMON Hisanori 新潟大学, 医歯学系, 助教 (00594350)
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | 口腔細菌 |
|---|
| Outline of Final Research Achievements |
We have been investigated (2R, 3R)-trehalose-6,6′-dicorynomycolate, and we named the material as a “Vizantin”. It revealed immunostimulating properties and anti-cancer response in vitro assays. In this present Challenging Explpratory Research, we synthesized or modified the insoluble Vizantin to soluble analogues, and then we used them for the analyses to search anti-bacterial biofilm molecules. The biochemical and imaging assays demonstrated that one of the Vizantin analogues inhibited Streoptococcus mutans biofilm formation.
|
| Free Research Field |
口腔細菌学
|
