Investigation for the receptor of dental pulp cell-derived tumor necrosis factor-alpha inducing factor (DPTIF)

2016 Fiscal Year Final Research Report

• Project/Area Number: 26670824
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Conservative dentistry
• Research Institution: Kyushu University
• Principal Investigator: NISHIMURA FUSANORI 九州大学, 歯学研究院, 教授 (80208222)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 歯髄細胞 / 急性炎症 / マクロファージ / TNF-α / 内毒素

Outline of Final Research Achievements

We previously found that dental pulp cells produces molecules inducing tumor necrosis factor alpha from macrophages, and named this factor Dental Pulp Cell-derived Tumor Necrosis Factor-α Inducing Factor: DPTIF. In this study, we aimed to unvail the nature of this molecule and to investigate the posibble receptor and/or binding proteins. The results indicated that DPTIF contains trypsin sensitive protenous molecule but is associated with extracelluler microvesicles. Therefore, it appeared that DPTIF is directly incorporated into macrophages rather than binding to the cell surface receptor.

Free Research Field

歯科保存学