Challenge to the non-invasive bone quality risk inspection by collagen cross-linking analysis.

2014 Fiscal Year Final Research Report

• Project/Area Number: 26670842
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Kyushu Dental College
• Principal Investigator: HOSOKAWA Ryuji 九州歯科大学, 歯学部, 教授 (60211546)
• Co-Investigator(Kenkyū-buntansha): MASAKI Chihiro 九州歯科大学, 歯学部, 助教 (60397940) ; KONDO Yusuke 九州歯科大学, 歯学部, 助教 (00611287)
• Co-Investigator(Renkei-kenkyūsha): GANEKO Kiyota 九州歯科大学, 歯学部, その他 (80759382)
• Project Period (FY): 2014-04-01 – 2015-03-31
• Keywords: 骨質 / ナノインデンテーション / コラーゲン架橋

Outline of Final Research Achievements

Bone strength defined by the bone density and bone quality is considered an important factor in dental implant treatment. However, it is difficult to evaluate the bone quality only preoperative CT scan, its objective evaluation methods are not established yet. In this study, we research on collagen cross-link in bone, using hyperhomocysteinemia model that is a non-enzymatic cross-link of bone increased by oxidative stress, bone non-enzymatic cross-link by measuring the brittle fracture strength It was intended to clarify the bone effect.
As a result, the experimental group in rabbit femur admit significant differences with respect to the maximum force and the breaking force. But the non-enzymatic cross-link is increased by Raman spectroscopy, so bone quality may change to "hard but brittle bones" .

Free Research Field

補綴・理工系歯学