2016 Fiscal Year Final Research Report
Establishment of novel therapy for regeneration of periodontal ligament (PDL) by application of the angiogenic and hematopoietic activities of PDL-derived cells
| Project/Area Number |
26670852
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 歯根膜 / 血管内皮前駆細胞 / 血管新生 / 造血能力 / 歯周組織再生 |
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| Outline of Final Research Achievements |
Aim of this study is establishment of novel therapy for regeneration of periodontal ligament (PDL) by application of the angiogenic and hematopoietic activities of PDL-derived cells.
Here, we found that hypoxic condition strongly promoted angiogenic and hematopoietic activities of the PDL-derived endothelial progenitor cells (EPCs) in the three-dimensional culture system by using type I collagen gel, which possibly facilitates identification of key genes for the expression of angiogenic and hematopoietic activities of these cells. In addition, we found that cell-cell interaction between EPCs and nerve cells possibly enhanced angiogenic and hematopoietic activities of EPCs. There is a possibility that establishment of microcirculation therapy through application of EPC―nerve cell network for angiogenesis and hematopoiesis.
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| Free Research Field |
細胞生物学、分子生物学
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