Strategic research on development of bone regenerative therapy with in vivo delivery of nucleic acids

2016 Fiscal Year Final Research Report

• Project/Area Number: 26670859
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: The University of Tokyo
• Principal Investigator: Takato Tsuyoshi 東京大学, 医学部附属病院, 教授 (90171454)
• Co-Investigator(Renkei-kenkyūsha): TEI Yuichi 東京大学, 大学院工学系研究科(工学部), 教授 (30345053)
• Research Collaborator: Hailati Aini
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 骨再生 / シグナル伝達

Outline of Final Research Achievements

This study aimed to examine the potential of the skeletal tissue repair by nucleic acid delivery to cells around tissue defects, and to develop basic technologies to achieve the therapy. First, nanomicelles encapsulating nucleic acids were optimized. Second, functional biomaterials carrying the nanomicelles were examined for their use in tissue repair. Lastly, in vivo experiments using the animal model of skeletal tissue degeneration revealed that the administration of nanomicelles encapsulating nucleic acids of a skeletogenesis-related factor suppressed the degeneration and repaired the degenerated tissues. Thus, this study provides a proof of concept for the skeletal tissue repair using nanomicelles that encapsulate nucleic acids of therapeutic genes.

Free Research Field

口腔外科学、再生医学