Approach to the mechanism of invasion and metastasis in oral squamous cell carcinoma from sphingolipid.

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670875
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Kanazawa Medical University
• Principal Investigator: KATO Koichiro 金沢医科大学, 医学部, 助教 (30719373)
• Co-Investigator(Kenkyū-buntansha): UEDA Yoshimichi 金沢医科大学, 医学部, 教授 (50271375)
• Co-Investigator(Renkei-kenkyūsha): OKAZAKI Toshiro 金沢医科大学, 医学部, 教授 (40233308)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 口腔扁平上皮癌

Outline of Final Research Achievements

Sphingosin kinase 1 is expressed in the invading squamous cell carcinoma (SCC) cells of the oral cavity. Expression of sphingosin kinase 1 is not related to the differentiation of the tumor cells. Sphingosin kinase 1 is not associated with proliferative activity of SCC of the oral cavity but epithelial-mesenchymal transition (EMT) of SCC cells. It is suggested that Grade 3 and 4C SCC cells require tumor cell-host cell interaction to upregulate SK1, and Grade 4D cells are not dependent on the interaction but able to upregulate SK1 by themselves and exhibit vigorous invading capability.

Free Research Field

口腔腫瘍