Utility of the M-test for oxaliplatin-induced peripheral neuropathy

2016 Fiscal Year Final Research Report

• Project/Area Number: 26670958
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Clinical nursing
• Research Institution: University of Miyazaki
• Principal Investigator: Oku Shoko 宮崎大学, 医学部, 教授 (40284921)
• Co-Investigator(Renkei-kenkyūsha): Shimoda kazuya 宮崎大学, 医学部, 教授 (90311844)
• Research Collaborator: Mukaino Yoshito ; Kubota Yuko ; Yonemaru Junko
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: オキサリプラチン / 末梢神経障害 / 大腸がん / M-Test

Outline of Final Research Achievements

We investigated the utility of the motion-induced somatic response test (M-test))in patients with peripheral neuropathy induced by oxaliplatin administered in the treatment of colorectal cancer. We evaluated subjective symptoms using questions set with reference to the Functional Assessment of Cancer Therapy (FACT; for neurotoxicity) version 4.0 and previous studies, and evaluated objective signs using thermography and the Japanese translation (JCOG version) of the Common Terminology Criteria for Adverse Events (CTCAE) version 4.0.Compared with NRS scores before M-Test, scores on the day after treatment were unchanged in four participants and had changed in eight participants. Before starting treatment, 15 participants reported a sensation of numbness and tingling pain in the hands or feet.Symptom diary: Participants wrote that numbness appeared to be alleviated slightly faster, that they developed an appetite. No noticeable changes were seen in blood test data,thermography and CTCAE

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