Development of effective wound care management methods for promoting wounds among older people focusing on acylated homoserine lactone.

2015 Fiscal Year Final Research Report

• Project/Area Number: 26671004
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Gerontological nursing
• Research Institution: The University of Tokyo
• Principal Investigator: Nakagami Gojiro 東京大学, 医学(系)研究科(研究院), 講師 (70547827)
• Co-Investigator(Kenkyū-buntansha): Sanada Hiromi 東京大学, 大学院医学系研究科, 教授 (50143920)
• Co-Investigator(Renkei-kenkyūsha): Minematsu Takeo 東京大学, 大学院医学系研究科, 特任講師 (00398752)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: クオラムセンシング / 創傷治癒 / 高齢者 / 糖尿病 / 緑膿菌 / 感染 / 褥瘡 / 動物実験

Outline of Final Research Achievements

Elderly people are suffering from intractable wounds due to the lack of proper wound healing. We aimed to develop a novel therapeutic method using quorum sensing signal (AHL). AHL topical application to the full-thickness wounds in diabetic rats showed inhibited inflammatory cell infiltration, enhanced proliferation of fibroblasts, and reduced oxidative stress. Furthermore, experiments using different length of acyl-acid of AHL revealed the C10-AHL promoted wound healing via neovascularization without inducing inflammation.

Free Research Field

創傷看護学