3D structural analysis of (macro)molecules using VCD in the region above 1900 cm-1

2016 Fiscal Year Final Research Report

• Project/Area Number: 26702034
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Biomolecular chemistry
• Research Institution: Hokkaido University
• Principal Investigator: Taniguchi Tohru 北海道大学, 先端生命科学研究科(研究院), 助教 (00587123)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 有機化学 / 赤外円二色性 / キラリティー / タンパク質 / 構造解析

Outline of Final Research Achievements

Development of a method to analyze molecular stereostructures provides a detailed understanding of the functions of various molecules such as medicines and enzymes and of the origin of life. This work has established a new convenient method for analyzing molecular stereostructures by using vibrational circular dichroism (VCD) spectroscopy. For example, this work has demonstrated its effectiveness toward the secondary structure of macromolecules such as polyesters. Another example for the use of our VCD method is facile determination of lipid molecules that are suggested to have involved in the development of life. Because VCD spectroscopy provides structural information that can not be obtained by the other available methods, this method should deepen our understandings on molecular stereostructures.

Free Research Field

天然物化学・キラル化学