Dye-Containing Organic-Inorganic Hybrid Materials for Photoacoustic Imaging Probes

2016 Fiscal Year Final Research Report

• Project/Area Number: 26708024
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Organic and hybrid materials
• Research Institution: Kyoto University
• Principal Investigator: MIKI KOJI 京都大学, 工学(系)研究科(研究院), 准教授 (60422979)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 近赤外色素 / 両親媒性 / ヒアルロン酸 / ナノ粒子 / 腫瘍 / 光音響

Outline of Final Research Achievements

Organic-inorganic hybrid materials consisting of hyaluronic acid, poly(ethylene glycol), and cyanine dyes, which absorb near-infrared light and generate ultrasound, so-called photoacoustic signal, were prepared. This materials formed nanoparticles in water, which generated photoacoustic signal efficiently under near-infrared pulse laser irradiation. When these nanoparticles injected to tumor-bearing mice, nanoparticles efficiently accumulated in tumor sites and visualized them in high contrast.

Free Research Field

有機合成化学