Elucidation of rupture mechanisms of aortas by observation of their microstructure at rupture site

2017 Fiscal Year Final Research Report

• Project/Area Number: 26709002
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Materials/Mechanics of materials
• Research Institution: Nagoya Institute of Technology
• Principal Investigator: Sugita Shukei 名古屋工業大学, 工学(系)研究科(研究院), 准教授 (20532104)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: バイオメカニクス / 細胞・組織 / 血管壁 / 破壊メカニズム / コラーゲン / エラスチン

Outline of Final Research Achievements

The mortality rate due to the rupture of the aortic aneurysm is still high. It is essential to investigate the rupture mechanism. In this study, simultaneous observation of the rupture phenomenon and microstructure of the aorta was performed to provide valuable insights into the rupture mechanisms. Porcine thoracic aortas were biaxially stretched under a microscope. The results showed that local density of collagen fibers was lower at the crack initiation sites. Local density of elastin and connection between elastin and collagen fibers were not related to the rupture sites. Basic researches to establish methods for quantification of sub-type of collagen fibers and observation of rupture of cylindrical shape of the aorta under a microscope were also performed.

Free Research Field

総合領域