2017 Fiscal Year Final Research Report
Development of molecular-specific cancer theranostics utilizing near-infrared light and monoclonal antibody
| Project/Area Number |
26710010
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Tumor therapeutics
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Research Collaborator |
ITO KIMIHIRO 東京慈恵会医科大学, 医学部, 助教 (60794336)
NISHIMURA TAKASHI 東京慈恵会医科大学, 大学院生
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | がん / 分子イメージング / 近赤外光 / 抗体療法 |
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| Outline of Final Research Achievements |
Photoimmunotherapy (PIT) is a recently developed molecular-targeted cancer theranostics based on conjugating a near-infrared photoactivatable fluorescence probe to a monoclonal antibody targeting cancer cell surface molecules. In this project, we have developed several methods to enhance therapeutic outcomes of PIT. (1) PIT in combination with chemotherapy (2) PIT utilizing two monoclonal antibodies recognizing different epitopes of cancer antigen. (3) PIT utilizing photoactivatable bifunctional antibody-drug conjugates.
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| Free Research Field |
腫瘍治療学
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