Understanding and chemical control of inflammation induced by innate immune system

2017 Fiscal Year Final Research Report

• Project/Area Number: 26713005
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Biological pharmacy
• Research Institution: The University of Tokushima (2015-2017); Osaka University (2014)
• Principal Investigator: SAITOH Tatsuya 徳島大学, 先端酵素学研究所(次世代), 教授 (60456936)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 炎症 / 自然免疫 / 生活習慣病 / 生体防御

Outline of Final Research Achievements

Innate immune system senses microbial components by pattern-recognition receptors and induces inflammation to eliminate invading microbes. However, innate immune system also senses nutrient-derived stimulatory factors and often causes development of inflammatory diseases. We have conducted studies of inflammation induced by innate immune system, and have revealed mechanisms of development of inflammatory diseases. Furthermore, we have identified chemical compounds capable of inhibiting inflammation induced by innate immune system and have revealed mechanisms of action of anti-inflammatory compounds.

Free Research Field

生物系薬学、免疫学