Structural basis for the mechanisms of virus entry into host cells

2016 Fiscal Year Final Research Report

• Project/Area Number: 26713018
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Virology
• Research Institution: Kyushu University
• Principal Investigator: Hashiguchi Takao 九州大学, 医学(系)研究科(研究院), 准教授 (50632098)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 感染症 / ウイルス / 蛋白質 / 構造解析

Outline of Final Research Achievements

To better understand the mechanisms of virus entry, we utilize combined strategies of Structural biology and Virology for mumps virus that causes epidemic parotitis and ebola/marburg virus that cause highly lethal hemorrhagic fever. As the results, we successfully visualized how the viruses enter into host cells at atomic level, which enabled us to better understand a part of the mechanisms of virus entry. These results will illuminate directions toward therapeutics against the viruses.

Free Research Field

ウイルス学