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2016 Fiscal Year Final Research Report

Elucidation of renin-angiotensin system roles in osteocyte and development of novel osteogenic medication.

Research Project

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Project/Area Number 26713048
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypePartial Multi-year Fund
Research Field Orthopaedic surgery
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Ochi Hiroki  東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (30582283)

Project Period (FY) 2014-04-01 – 2017-03-31
Keywords骨細胞 / レニンアンギオテンシン系
Outline of Final Research Achievements

In this study, we evaluated the significance of the renin angiotensin system in osteocytes by using osteocyte-specific RAS related gene deficient mice. These conditional knockout mice showed excessive bone mass in cortical bone. Osteoblast activities in cortical bone were significantly increased by bone morphological analysis. These findings suggest that RAS related gene in osteocyte regulates osteoblast function negatively and then maintains bone remodeling.

Free Research Field

骨代謝

URL: 

Published: 2018-03-22  

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