2016 Fiscal Year Final Research Report
Elucidation of renin-angiotensin system roles in osteocyte and development of novel osteogenic medication.
| Project/Area Number |
26713048
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Ochi Hiroki 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (30582283)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 骨細胞 / レニンアンギオテンシン系 |
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| Outline of Final Research Achievements |
In this study, we evaluated the significance of the renin angiotensin system in osteocytes by using osteocyte-specific RAS related gene deficient mice. These conditional knockout mice showed excessive bone mass in cortical bone. Osteoblast activities in cortical bone were significantly increased by bone morphological analysis. These findings suggest that RAS related gene in osteocyte regulates osteoblast function negatively and then maintains bone remodeling.
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| Free Research Field |
骨代謝
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