Establishment of practical cell therapy to control chronic inflammation of diabetic ulcer

2017 Fiscal Year Final Research Report

• Project/Area Number: 26713051
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Plastic surgery
• Research Institution: Juntendo University
• Principal Investigator: Tanaka Rica 順天堂大学, 医学部, 先任准教授 (70509827)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 糖尿病 / 慢性炎症 / 再生医療 / 細胞治療 / 創傷治癒 / 皮膚 / マクロファージ / 血管幹細胞

Outline of Final Research Achievements

This project revealed the cause of diabetic wound chronic inflammation and the major factor responsible for its mechanism. In addition, the applicant established a newly founded ex vivo expansion system which enhances the function of diabetic peripheral blood mononuclear cells that can be effective for diabetic wound healing by changing the inflammatory wound environment to anti-inflammatory regenerative state. These findings have built the bases for establishing highly effective cell therapy for diabetic wound healing. Furthermore, the treatment predictor bio-marker candidates for cell therapy found in this study will lead us to establishing personalized treatment strategies according to gene characteristics.

Free Research Field

形成外科