2015 Fiscal Year Final Research Report
The mechanism of generation of reactive oxygen species and oxidative neuronal injury induced by methylmercury
| Project/Area Number |
26740024
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Risk sciences of radiation and chemicals
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | メチル水銀 / 活性酸素 / 酸化ストレス / ミトコンドリア / MRI |
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| Outline of Final Research Achievements |
The purpose of this study is to reveal the mechanism of oxidative neuronal injury induced by methylmercury. Reactive oxygen species (ROS) derived from mitochondria were shown to be involved in neurotoxicity induced by methylmercury using mitochondrial DNA depleted SH-SY5Y cells. Brain region specific oxidation was detected in mice administered with methylmercury. The relationships between region specific generation of ROS and behavior disorder induced by methylmercury will be examined in the future.
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| Free Research Field |
環境毒性学
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