Study of nutritional metabolism and feeding schedules for dietary therapy based on the chrono-nutrition

2016 Fiscal Year Final Research Report

• Project/Area Number: 26750051
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Eating habits
• Research Institution: Tohoku Womens College (2015-2016); Prefectural University of Hiroshima (2014)
• Principal Investigator: NISHIDA Yuka 東北女子大学, 家政学部, 教授 (40435053)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 時間栄養学 / 摂食時刻 / 高砂糖食 / 高塩食 / 摂食パターン / 脂質代謝 / 時計遺伝子 / 尿排泄リズム

Outline of Final Research Achievements

We examined the effect of irregular feeding schedules on the daily rhythms of hepatic genes expression in rats. Rats in control and late supper groups displayed similar expression profiles of hepatic genes (Bmal1, Pparα, and Cpt1a), whereas the peak phase of those genes in late breakfast group were delayed. These results suggest that the time of first feeding on the active period determines the circadian rhythm in the liver. Next, we examined the effect of feeding time of excess sugar in rats consumed the same amount of diets per day. The liver levels of triglyceride increased by feeding excess sugar on the latter timing of active period. On the other hand, the insulin resistance was caused regardless of feeding time of excess sugar. The chrono-nutritional concept for each disease is necessary to the prevention and treatment of lifestyle-related disease.

Free Research Field

臨床栄養学