Fundamental study on artificial control of glucose and lipid metabolism with microstimulation of peripheral sympathetic nerve fascicle

2016 Fiscal Year Final Research Report

• Project/Area Number: 26750141
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Yamagata University
• Principal Investigator: Sato Daisuke 山形大学, 大学院医学系研究科, 助教 (60536960)
• Research Collaborator: NAKAMURA Takao 山形大学, 大学院医学系研究科, 教授 (00142654) ; KUSUNOKI Masataka 名古屋大学, 総合保健体育科学センター, 寄附研究部門教授 (80214956) ; NISHINA Atsuyoshi 日本大学, 理工学部, 教授 (00469884) ; TSUTSUMI Kazuhiko 徳島文理大学, 薬学部, 特任教授
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 末梢交感神経 / 糖取り込み / 脂肪酸組成

Outline of Final Research Achievements

To develop the novel method for artificial control of glucose and lipid metabolism without exercise and drug, we investigated the effects of microstimulation of peripheral sympathetic nervous system on glucose and lipid metabolism. As a result of the microstimulation of sympathetic nerve fascicle in the unilateral sciatic nerve in rats, the stimulation enhanced systemic glucose uptake without change in plasma insulin level. In addition, the stimulation for 1 h elevated gene expression of Cox4 in epididymal adipose tissue in rats, suggesting increase in mitochondria. In conclusion, the microstimulation of peripheral sympathetic nerve fascicle enhanced non-insulin-mediated glucose uptake systemically and fat oxidation in adipose tissue.

Free Research Field

生物工学