2016 Fiscal Year Final Research Report
Regulating mechanism of mitochondrial function by BDNF in the skeletal muscle
| Project/Area Number |
26750331
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied health science
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| Research Institution | Hokkaido University |
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Principal Investigator |
Takada Shingo 北海道大学, 医学研究科, 博士研究員 (60722329)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | ミトコンドリア / 骨格筋 / マイオカイン / 心不全 / 老化・加齢 / マイトファジー / 脳由来神経栄養因子 / ミトコンドリアダイナミクス |
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| Outline of Final Research Achievements |
Brain-derived neurotrophic factor (BDNF), a member of the neurotrophic factor family, has been known to be increased by exercise training and associated with exercise capacity (Int J Cardiol 2013), which are dependent on mitochondrial function in the skeletal muscle. BDNF-TrkB pathway may play an important role in the improvement of the beneficial effects of exercise training on the exercise capacity and skeletal muscle mitochondrial function.
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| Free Research Field |
健康医科学
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