Construction of amylose hybrid polymer library for next-generation chaperone system.

2015 Fiscal Year Final Research Report

• Project/Area Number: 26810113
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Polymer/Textile materials
• Research Institution: Kyoto University
• Principal Investigator: Nishimura Tomoki 京都大学, 工学(系)研究科(研究院), 研究員 (60648070)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: アミロース / 酵素重合 / シャペロン

Outline of Final Research Achievements

We prepared a library of amphiphilic amylose-based star copolymers using a copper catalyzed click reaction. We then evaluated chaperon function of a series of these molecules for heat denatured carbonic anhydrate and optimized chemical structure for chaperon functioning polymer. We also synthesized a novel light-sensitive nanogel using cholesterol modified with an ortho-nitrobenzyl unit on the hydroxyl group of pullulan. The use of light-sensitive components makes it possible to create patterned nanogel films that can immobilize proteins. The preparation of patterned materials is important for the construction of micro- or nanodevices such as MEMS and biomolecular chips.

Free Research Field

生体高分子