Remodeling of nuclear transport system in terminal differentiation of cortical neurons

2016 Fiscal Year Final Research Report

• Project/Area Number: 26830047
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Osaka University
• Principal Investigator: Fujiwara Kazushiro 大阪大学, たんぱく質研究所, 助教 (80638495)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: ニューロン / 分化 / RanGAP1 / SUMO

Outline of Final Research Achievements

Neuronal terminal differentiation rapidly promoted desumoylation of RanGAP1 and reduced the levels of nuclear pore-associated RanGAP1. Downregulation of RanGAP1 expression impeded the nuclear import of nucleocytoplasmic shuttling proteins including the DNA replication initiation factor Cdc6 and accelerated cell cycle exit of neuronal progenitors. These results suggest that remodeling of the RanGAP1-mediated nuclear transport system plays a key role in cell cycle exit for terminal differentiation of cortical neurons.

Free Research Field

分子神経細胞生物学