FROM THE QUESTION OF HOW GLIAL CELLS WRAP THEIR MEMBRANE WITH AXONS TO THE POSSIBLE SOLUTION OF HOW DEMYELINATING DISORDERS WERE RECOVERED

2016 Fiscal Year Final Research Report

• Project/Area Number: 26830054
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: National Center for Child Health and Development
• Principal Investigator: Miyamoto Yuki 国立研究開発法人国立成育医療研究センター, 薬剤治療研究部, 研究員 (50425708)
• Research Collaborator: KAWAHARA Kazuko 国立成育医療研究センター
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 髄鞘 / グリア細胞 / 神経細胞 / 共培養

Outline of Final Research Achievements

During postnatal development in the central nervous system (CNS), oligodendrocytes differentiate to wrap their plasma membranes around neuronal axons, forming the myelin sheath. Although a neuronal cue is one of the regulator elements controlling this process, the overall picture remains elusive. Our experiments using microarray analysis in primary oligodendrocytes have revealed that vascular cell adhesion molecule (VCAM) 1, which plays a key role throughout the immune system, is one of their transcripts. VCAM1 contributes to the initiation of myelination through ligand ligation , demonstrating that an intercellular molecule whose primary role is in the immune system can also play an unexpected role in the CNS.

Free Research Field

神経化学