2015 Fiscal Year Final Research Report
Analysis of regulatory mechanism of tumor angiogenesis by Tie1 ectodomain
Project/Area Number |
26830072
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Tumor biology
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Research Institution | Osaka University |
Principal Investigator |
YAMAKAWA DAISHI 大阪大学, 微生物病研究所, 特任研究員(常勤) (20631097)
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Keywords | 腫瘍血管新生 / 血管新生阻害 / 蛋白質分解酵素 |
Outline of Final Research Achievements |
Suppression of tumor angiogenesis suppress penetration of nutrients into tumor, resulting in tumor growth suppression. It is known that receptor tyrosine kinase Tie1 associates with vascular stabilization. In this study, we focused on the function of Tie1 ectodomain which is cleaved by angiogenic stimulation. We identified that Tie1 ectodomain suppresses pathological angiogenesis via direct interaction with endothelial cells in vitro and in vivo. In the future, we hope to establish the induction method of Tie1 ectodomain shedding or regulation method of Tie1 ectodomain binding molecule in tumor vasculature.
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Free Research Field |
血管生物学
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