Effects of NAD+ metabolism on cellular senescence/tumorigenesis

2015 Fiscal Year Final Research Report

• Project/Area Number: 26830074
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Tumor biology
• Research Institution: Nara Institute of Science and Technology
• Principal Investigator: NAKAHATA Yasukazu 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (50390810)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 細胞老化 / NAD+代謝

Outline of Final Research Achievements

We revealed that NAD+ metabolism in mouse embryonic fibroblasts affects “cellular senescence” and “tumorigenesis”. Fibroblasts derived from the mice having enforced overexpression of NAMPT, the rate-limiting enzyme in NAD+ salvage pathway delay the onset of cellular senescence and Ras-induced transformed MEF cells derived from Tg mice demonstrate less potential against anchorage-independent growth. These results suggest that in mice fibroblast to keep NAD+ level high works negative for processes of cellular senescence and tumorigenesis.

Free Research Field

時間生物学