2016 Fiscal Year Final Research Report
Turnover of receptor tyrosine kinases regulated by membrane trafficking
| Project/Area Number |
26830080
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
WAGURI SATOSHI 福島県立医科大学, 医学部, 教授 (30244908)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | ゴルジ体 / エンドソーム / 受容体型チロシンキナーゼ / 小胞輸送 / タンパク寿命調節 / ノックダウン / 細胞増殖 / 癌 |
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| Outline of Final Research Achievements |
GGAs (GGA1,2,3) and AP-1 are membrane trafficking associated molecules and they function as clathrin adaptors. Their functions have been investigated in terms of quality control of protein using cell lines. Depletion of GGA2 or AP-1 complex decreased EGFR expression at protein level, reflecting enhanced lysosomal degradation of EGFR. This result suggests that GGA2 and AP-1 complex are involved in protein transport of transmembrane protein at the post-Golgi compartments to regulate the turnover. Also, this raises a possibility that the malfunction of GGAs and AP-1 could influence pathologies such as neurodegenerative diseases or cancer.
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| Free Research Field |
細胞生物学
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