2016 Fiscal Year Final Research Report
Elucidation of tumor suppression mechanism through identification of novel proteins involved in mismatch repair-dependent apoptosis
| Project/Area Number |
26830085
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | ミスマッチ修復 / アポトーシス / アルキル化剤 |
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| Outline of Final Research Achievements |
O6-methylguanine (O6meG) can form O6meG/T mispair during DNA replication. The mismatch repair (MMR) complex recognizes this mispair and activates cell cycle checkpoint followed by apoptosis induction. The precise molecular mechanism of this apoptotic pathway is still unclear. In order to unveil molecular mechanism of the apoptotic pathway, we tried to purify proteins which can function or associate with MMR complex. We successfully identified three MMR-associated proteins as new apoptosis-related factors. Analyses of these factors will shed light on understanding of molecular mechanism of tumor suppression and developing new anti-cancer drugs.
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| Free Research Field |
分子生物学
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