2015 Fiscal Year Final Research Report
Construction of the treatment algorithm for triple negative breast cancer
| Project/Area Number |
26830094
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor diagnostics
|
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | トリプルネガティブ乳癌 / 腫瘍浸潤リンパ球 |
|---|
| Outline of Final Research Achievements |
TNBCs with a high CD8+/FOXP3+ ratio were more sensitive to anthracycline and taxane based chemotherapeutic regimens, and the CD8+/FOXP3+ ratio in conjunction with Ki-67 could predict pCR following NAC in TNBC. And we demonstrate that high CD8+ TIL and a high CD8/FOXP3 ratio in residual tumors and increment of these parameters following NAC and accurately predict improved prognosis in TNBC patients with non-pCR following NAC. These parameters could serve as a surrogate one for adjuvant treatment in patients with residual disease in the neoadjuvant setting.
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| Free Research Field |
腫瘍外科学
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